Renal Albumin Excretion

Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury.

This study evaluated the potential utility of albuminuria as a "biomarker" of acute kidney injury (AKI) and tested whether AKI induces renal expression of the normally silent albumin gene. Urine albumin concentrations were measured in mice with five different AKI models (maleate, ischemia-reperfusion, rhabdomyolysis, endotoxemia, ureteral obstruction). Albumin gene induction in renal cortex, an...

Albumin excretion rate among patients with diabetic retinopathy

Increased albumin excretion in diabetes.

In 1964 Keen and Chlouverakis used a radioimmunoassay to measure the concentration of albumin in the urine of diabetic subjects.' Although the urine samples were negative for protein by standard clinical tests, the rate of albumin excretion in the study group was greater than in normal controls. Many studies and review articles have subsequently addressed the clinical implications and pathophys...

Influence of strenuous exercise on albumin excretion.

Renal albumin excretion rate was 7.3 mg/24 h (SEM 0.5, range 0.6-21.0) in 66 healthy subjects. This rate increased markedly during and shortly after strenuous exercise on a bicycle ergometer (before: 5.5 +/- 0.6 micrograms/min; during and just after: 16.9 +/- 2.2 micrograms/min; P less than 0.001; n = 30). However, albumin excretion/24 h was not significantly higher during 24 h with a period of...

Urinary albumin excretion is associated with renal functional abnormalities in a nondiabetic population.

Microalbuminuria (MA) is an important early sign of diabetic nephropathy. Hyperfiltration and impaired filtration in relation to albuminuria has been well investigated in diabetic subjects. This study tested the hypothesis that an increased urinary albumin excretion (UAE) is associated with renal functional abnormalities also in nondiabetic subjects. The relation between UAE and creatinine clea...